Only three years after Insys Therapeutics, Inc., placed Subsys on the market in 2012, the drug has already earned record profits for the company, earning $147.2 million for Insys during the first six month of 2015 alone.
Subsys is the first and only fentanyl sublingual medicine that is sprayed under the tongue and which claims to be able to relieve adults with cancer from breakthrough pain in as little as five minutes. Due to the major content of this medication, however, fentanyl, which belongs to a class of drugs known as opiate or narcotic analgesics, Subsys can cause abuse, overdose, addiction, or death. These risks made the U.S. Food and Drug Administration require that the purchase of Subsys be permitted only to healthcare professionals who prescribe Subsys to outpatients, to outpatients, to distributors and pharmacies, enrolled in the Transmucosal Immediate-Release Fentanyl (TIRF) REMS Access program.
Besides the fact that Subsys should be used only by adult cancer patients who are opioid tolerant, warning is strongly made against sharing this medicine with people to whom it has not been prescribed, but most especially against using it on children since its fentanyl content can prove fatal to a child.
For Subsys users, side-effects of this medicine include, but are not limited to: breathing problems (especially to severely ill and malnourished patients), drowsiness, allergic reaction (like swelling of face, lips, tongue, or throat), slow heart rate, severe drowsiness, feeling like passing out; rapid heart rate, confusion, extreme fear, unusual thoughts or behavior, and trouble concentrating. For pregnant women, use of Subsys can cause their baby to become dependent on fentanyl which, in turn, can cause life-threatening withdrawal symptoms after the baby is born.
Besides being accused of illegally promoting Subsys to doctors in ways that violate of FDA rules, Fentanyl spray lawsuit also link use of Subsys to overdose in patients.
Hair loss is a common symptom among patients undergoing chemotherapy; their hair usually grows back within three to six months after treatment has stopped. About 10-15% of women, who were treated with Taxotere, however, reported no hair growth for as long as ten years after chemotherapy treatments. Permanent hair loss, or Alopecia, comes in many different forms, including:
- No hair growth under arms or around genitals;
- Lack of eyebrows and eyelashes; and,
- Total hair loss on the scalp and body (this is the most common result reported of Taxotere use; this special form of alopecia is called “alopecia universalis”)
Taxotere (with the Generic name Docetaxel) is an intravenous chemotherapy drug manufactured by Sanofi-Aventis. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of various cancers including non-small cell lung cancer, prostate cancer, breast cancer, gastric cancer, and head and neck cancer. Specific use of Taxotere (in combination with doxorubicin and cyclophosphamide) for treatment of operable node-positive breast cancer in women was approved by the FDA on August 18, 2004.
The law firm Williams Kherkher explains in its website that, as early as 2005, patients outside of the U.S. were warned about permanent hair loss. Sanofi-Aventis, however, only began warning patients in the U.S. of the risk of permanent alopecia in December of 2015, after it was mandated to do so by the FDA.
Currently, lawsuits have been filed by women who have, or formerly had, breast cancer and are now suffering permanent alopecia due to treatment with Taxotere. Besides the hair loss condition, these women, through their lawsuits, also want to understand why equally effective alternative chemotherapy drugs were not prescribed to them despite the risk that come with Taxotere use.
The lawsuits need to prove claims that Sanofi-Aventis deliberately concealed the risks associated with using Taxotere despite its awareness of the drug’s side-effects as early as the 1990s, as well as allegations that it incentivized doctors to continue prescribing the drug to unsuspecting women.
For some people, flying in a plane can be exciting. One cannot help but be awed by the sight of the clouds and the tiny houses. On the other hand, some people also have apprehensions for flying. According to the website of Williams Kherker, the extreme height and speed involved in an airplane makes aviation accidents devastating.
Figures from the National Safety Council gives us an assurance that the odds of dying in an aviation accident is at about 1 in 7,178 compared to a car which is at 1 in 98. In addition, a report by OAG Aviation and PlaneCrashInfo.com places the odds of death in one of the top 78 major world airlines is one in 4.7 million. But luck will not always be on the side of the passenger. Here are 5 common causes of plane accidents:
- Pilot Error. Half of all plane crashes were due to pilot error. This is quite understandable considering that pilots have a lot to do in the airplane. They navigate through dangerous waters, respond to mechanical issues, oe execute a safe takeoff and landing. Accidents result from pilots miscalculating equipment, misjudging weather conditions, or their failure to recognize mechanical errors.
- Mechanical Error. Mechanical error accounts for 22% of all aviation accidents. When situations like this happens, the pilot is at the mercy of the planer. Mechanical errors may be caused by errors in the plane’s design. Some examples of plane crashes due to mechanical errors include the 1974 crash of a Turkish Airlines flight to France and a 1955 West African Airways flight. The former crashed due to a flaw in the latch of a cargo door while the latter crashed as a result of flaws in its wing design.
- Weather. 12% of plane crashes were due to weather conditions. Although flights are usually cancelled during hazardous conditions such as storms or heavy winds and even fog can be a challenge for pilots and air traffic controllers. Lightning can disable planes in a variety of ways. It can cause electrical failures, ignite fuel tanksand pipes, and others.
- Sabotage . A clear example of a plane accident due to sabotage was the 9/11 accident where threre flights were hijacked and crashed into the two World Trade Center towers. Although the TSA has strict regulations, passengers can still sneek in bombs or firearms into planes.Sabotage accounted fo 9% of total crashes.
- Other Human Error. 7% of plane crashes are atrtributed to other human error. Examples would be air traffic control mistakes, overloaded planes, improper fuel load or maintenance errors.
The Centers for Disease Control and Prevention (CDC) consider salmonella contamination as the most common type of food poisoning in the U.S. According to the agency, salmonella contamination accounts for about 1.2 million recorded illnesses and 450 fatalities every year, which also makes it one of the deadliest food-borne illnesses in the country.
Although anyone can suffer from salmonella infection, younger children, older adults, and those suffering from immune-related diseases are at highest risk of serious, sometimes even fatal health complications. Furthermore, healthy individuals are at risk of dehydration due to diarrhea and other gastrointestinal disorders. So, it is important to seek medical help if you have been exposed to salmonella infection to prevent long-term, and possible fatal complications.
Lawyers from the Law Offices of Ronald J. Resmini, LTD., know how food products manufactured and packed in an unsanitary way may pose health hazards to consumers. But apart from negligent food manufacturers, there will always be a risk of salmonella infection even when preparing meal yourself. Your risk of salmonella increases when:
- You consume unpasteurized milk and milk products.
- You consume uncooked or undercooked meat, meat products, or eggs. Meat and meat products, such as delis, should be cooked under enough heat to kill pathogens, including salmonella.
- You are preparing/handling ready-to-eat food products without washing your hands. Salmonella bacteria can oftentimes be found in fecal matters of animals and humans; and preparing food products without washing your hands in between every process may cause cross-contamination.
- Utensils, plates, and other kitchen implements used for raw, uncooked food were also used for cooked, ready-to-eat products.
The effects of salmonella infection can be life-changing, especially for those with weak immune system. Symptoms of salmonella infection include diarrhea and muscle aches. So, if you think you have been exposed to salmonella contamination and are experiencing some of its symptoms, you should seek medical help right away for quick diagnosis and treatment.
A case of personal injury can be difficult to prove alone – especially if one is not exactly the most knowledgeable with legal terminologies and such.
For example, according to the website of The Seegmiller Law Firm, the definition of personal injury can be phrased to mean an injury that has been dealt upon a person due to the negligent actions of another party. A definition like this accounts for many variables and these different factors are then separated into subsets in order to be dealt with accordingly through systematic, just means.
For example, say you were walking past a garden where a few kids were playing baseball and they manage to hit you in the face by accident. It causes a bruise for you. Technically, this can be a case of personal injury due to the definition of the phrase. However, is it really worth pursuing to file legal action against a few kids for a bruise that will probably fade in a few days? The deal is entirely different if you were, for example, at a baseball game and say a part of the stadium collapsed on you and caused severe, permanent injury.
The injury begets medical treatment and even compensation for the loss of wages that are certain to be had due to the temporary or permanent inability to go to work. Not to mention the emotional trauma that something so devastating can cause on you and your loved ones. Personal injury was not created as a means to glorify being made the victim but in order to allow for those who have survived horrible accidents such as this, the means to demand justice and compensation for the wrong that was done onto them.
Madison is more than just its scenic views and breathtaking waterways. Wisconsin’s capital city is also pulsating with a diverse culture and a rich academic tradition. Visitors who want to experience the lifeblood of Madison can explore the many universities and colleges that make up the city that is often considered as one of the best places in the United States for education.
University of Wisconsin – Madison
University of Wisconsin – Madison is a world-class institution, responsible for helming over 42,000 students ever year. It has a campus comprising of 933 acres and is just about a mile from the Wisconsin Capitol building in the heart of downtown Madison. The sprawling campus is accentuated by state of the art facilities and architecturally innovative buildings. Visitors should make it a point to stop by the Chazen Museum of Art and the Wisconsin Institutes for Discovery. Those who want to enjoy the scenery and stroll through the campus can drop by the Allen Centennial Gardens and Wisconsin Memorial Union.
This Dominican run Catholic college is just off the shore of Lake Wingra. Edgewood College is the only independent liberal arts institution in Madison, with about 1,800 students in its campus. The highlights of the quaint and intimate campus area are the DeRicci Gallery and the Regina Theater. The first is a place where visitors can view exhibits by students and local artists. Meanwhile, the theater is the usual venue for choral and band concerts, as well as some theatrical productions.
Madison College is a place for individuals looking to obtain associate degrees and professional certificate programs through technical training. As a community college, the institution is said to be responsible for the education of about 50,000 students every year. Visitors can drop by the Mitby Theater to witness student-run productions, as well as a number of choral and instrumental performances.
Xarelto, or rivaroxaban, is used as a blood thinner to prevent blood clots from forming that was approved by the U.S Food and Drug Administration in 2011. It is a popular medication after hip or knee replacement surgery or when an individual has irregular heartbeats to prevent strokes. The anticoagulant works by preventing blood clotting proteins from forming. The most common type of blood clot treated with Xarelto is called deep vein thrombosis which can cause pulmonary embolisms.
The side effects of Xarelto range from bruising to immobility or death. The most common side effects of Xarelto include:
- Unusual or continuous bleeding
- Headache or dizziness
- Red or pink urine
- Loss of movement in any part of the body
According to attorneys, Xarelto was recently prohibited from treating acute coronary syndrome due to the associated side effects of the drug. There have also been cases of allergic reactions to Xarelto. Reported cases of this include symptoms of hives, difficulty breathing, and swelling of facial features.
Xarelto is dosed in 10 mg strength tablets. The tablet is generally prescribed to be taken orally once a day with or without food and water. When hemostasis occurs after surgery, the first dose of Xarelto is encouraged within a 6 to 10 hour time frame. The drug differs from most other blood thinners since it does not require blood testing. Coumadin, an older and substantial competitor to Xarelto, also requires dietary restrictions along with routine blood work. The convenience of the medication also came with an increased sticker price that was more than ten times the cost of annual cost of similar drugs.
Bayer and Johnson & Johnson benefit enormously from the drug, receiving about $1 billion from sales worldwide. The successful drug, however, is recently involved in several cases of severe bleeding that have resulted in death. Xarelto manufacturers and the drug itself are now under fire for the unlisted side effects that present a danger to their prescribed patients.
Choosing a self-storage facility that you can trust with the safety of your belongings is important to keep peace of mind. There are a number of steps you can take to protect yourself and your belongings when it comes to picking and maintaining a self-storage unit. When choosing a facility to store your belongings, consider the security measures, amenities, access schedule, size of units offered, and maintenance of the area.
There are storage units of all sizes and amenities to choose from. Many storage units will include a stable temperature control to keep belongings from becoming too hot or cold when the seasons change. Other storage facilities are more basic, offering shelter and little else. However, it is still important for all types of storage spaces to offer security, quality customer service, and a cleanly and pest-free environment. Make sure you don’t overlook these services.
After choosing the storage facility, there are packing tips that will elongate the life of the stored items. Here is a list of tips to packaging possessions:
- Box all stored items in sturdy boxes that are completely filled
- Do not store wet items in storage units
- Avoid plastic bags or containers, humidity can build and cause mildew
- Package clothes and breakable objects in containers specifically designed for that item
- Spray wood furniture with furniture spray to protect it
- Do not store photographs in storage units that do not have a climate controlled setting
The website of Mopac Self Storage also advises against using newspaper to pack belongings because the ink can attach itself to the wrapped items. There are other packing papers that will not cause this problem. Bubble wrap is another option for more fragile belongings that require extra protection.
Renting a storage unit should be an easy solution to your space problem. If you are in need of a safe area to store your belongings, find several self-storage facilities in your area that provide the kinds of services you are looking. Only after visiting the units, make an informed decision about where to place your valuable belongings.
Construction is one of the most hazardous industries to work in. There are four major ways that a worker or the public can be at risk. These are accidents involving electrocution, caught-in, falls, and falling objects. Many cases of construction accidents are a result of the construction company failing to provide the appropriate safety gear or training for worker protection, which can sometimes spill over to non-worker injuries as well.
According to the website of law firm Hach & Rose, falling objects is one of the more common hazards that can strike workers and members of the public, especially in high-rise projects where even the smallest objects can gain enough momentum to do serious damage to anyone or anything in its downward path. It is not necessarily a hammer or wrench; a nail falling from a hundred stories up attain the force of a high-speed bullet at those heights.
This is the reason why the Occupational Safety and Health Administration (OSHA) urge construction companies and workers to observe safety regulations. Any work done more than 6 feet up should include the use of debris mats and other falling object prevention measures. Workers are directed not to stay under a crane in operation and to wear safety hats at all time while at the worksite.
Tools used in construction need to be secured whether in use or not, and all construction materials such as wood, nails, steel bars, and the like need to be likewise secured to prevent being inadvertently dislodged and falling on workers on a lower level or on pedestrians and vehicles that may be passing on the ground below.
When construction accidents happen that involves falling objects, the contractor or construction company is liable for any injury or property that may occur if it is proven that they failed to follow safety regulations. If you have been seriously injured because of negligence at a construction site, you may be eligible to get compensation. Consult with a construction accident lawyer at the earliest possible time.
Reasonable people are expected to take reasonable steps to prevent harm to themselves and to others against hazards that are out in the open and obvious even to an untrained perception. This is basically the definition of the open-and-obvious doctrine that is typically used as a defense in premises liability cases, and in general results in a summary judgment (dismissal) when the hazard proves to be open and obvious. In other words, it hinges upon the personal responsibility and common sense of people to make sure they don’t hurt themselves. However, like in anything legal, this is not as simple as it seems.
In Kentucky, recent Supreme Court rulings on two unrelated premises liability cases qualified the open-and-obvious doctrine which could significantly impact how premises liability cases, specifically slip-and-falls, are conducted in the future. The ruling basically says that a premises owner is guilty of a breach of duty to its invitees if there is a failure to do more to obviate the dangers posed by a hazardous situation, regardless of whether the hazard itself was open and obvious i.e. wires for medical equipment in a hospital room, and which failure resulted in an injury to the plaintiff.
According to the website of the Sampson Law Firm in Louisville, property owners in Kentucky owe a duty to invitees to eliminate potential risks for harm. As such, they share some responsibility for any harm that does occur to invitees even when the danger is open and obvious. Based on this, the Supreme Court states that the open-and-obvious doctrine was incompatible with the pure comparative fault system in place in Kentucky. Pure comparative fault allows a plaintiff to recover damages in tort cases even if the plaintiff is 99% at fault. That 1% fault of the defendant is enough to make the case viable, although whatever award is given is reduced by the plaintiff’s share of the fault. In essence, what these rulings denote is that the result is most likely to go against the defendant in a slip-and-fall lawsuit.
If you have been injured in a slip and fall accident in Kentucky, you have a very good chance of getting compensation. Consult with a skilled premises liability lawyer in your area as soon as possible.